Faizon Love got his start as a stand-up comedian at age 15 and made his acting debut in an Off-Broadway at the age of 19. His motion-picture debut, Bebe's Kids, had him providing the voice of comedian Robin Harris, who died before production began on the film; Love offered a close vocal impression of Harris. He then had a role in The Meteor Man, starring Robert Townsend. Townsend then cast Love in a co-starring role on his sitcom The Parent 'Hood.
He followed up this role with a breakout performance as the drug supplier Big Worm in the 1995 film Friday. Follow-up films have included 3 Strikes, Elf, Don't Be a Menace to South Central While Drinking Your Juice in the Hood, Money Talks, Wonderland, The Fighting Temptations, and Idlewild. In 2001, Love guest-starred in the Ludacris single "Freaky Thangs" from the album Word of Mouf. The same year, he made a cameo appearance as a bus driver, in the music video for Lil Jon & The East Side Boys' single "Put Yo Hood Up".
Love co-starred in Couples Retreat (2009), a comedy film chronicling four couples who partake in therapy sessions at a tropical island resort. In 2011 Love starred in a theatrical production of Our Town by Thornton Wilder, alongside Washington Wizards teammates Gilbert Arenas and Etan Thomas. In 2012, he played the role of Stringer Bell in the satirical trailer for The Wire: The Musical.